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Use of GLP-1 Receptor Agonists Prior to Surgery: When to Hold

By Lindsay Rakowski posted 21 days ago

  

Hello, my name is Lindsay, and I am a PGY-1 inpatient pharmacy resident. I am currently doing a drug investigation on when to hold GLP-1 receptor agonist injections (Trulicity, Ozempic, Mounjaro/Zepbound, etc.) prior to any surgery. At my institution, the practice has been to hold off on giving the injection for 7 days prior to surgery. The question has become, is 7 days enough time for the GLP-1 RA to not have an effect on the return of bowel function after surgery? And, if it is given sooner, will that effect the patient's outcome after surgery? I was wondering if there are other practitioners on here that have had experience with this subject and how long your institution holds a GLP-1 RA injectable before a surgery (can be GI-related surgery but not required). Thank you so much in advance for taking the time to read this and sharing your feedback! 

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